In this talk Dr. Wilson will present the preliminary outcomes of partnership building work among researchers from the University of Lethbridge, Universidad San Francisco de Quito (Ecuador) and Sacha Awana of the Indigenous Quijos Nation of Ecuador’s Amazon. The program of research emerging from this partnership examines issues of territorial sovereignty and women’s Indigenous leadership in the activation and application of Indigenous Knowledge Systems and Traditional Ecological Knowledge in processes of socioecological restoration. The partnership has subsequently evolved into a Nation-to-Nation and intersectoral cooperation including the Kainai Ecosystem Protection Association. He will also discuss some of the challenges of conducting research with Indigenous partners stemming from granting agencies’ funding structures and regulations.